TITLE:
Use of Bioelution as a Screening Tool for Characterisation of Substances
AUTHORS:
Noömi Lombaert, Carol Mackie, Violaine Verougstraete, Tony Brouwers, Frank Van Assche, Adriana Oller
KEYWORDS:
Metals, Grouping, Bioelution, Information Requirements, Read-Across
JOURNAL NAME:
American Journal of Analytical Chemistry,
Vol.9 No.3,
March
13,
2018
ABSTRACT: Bioelution, the measuring of in vitro metal ion release from metals or metal compounds in
simulated body fluids, can be used as a tool to measure bioaccessibility of
metals and metal compounds, and as such provide an estimate of their
bioavailability. Comparable bioelution results can allow grouping of substances
within a “metal” family. By referring to toxicity data on a metal substance (reference substance) within the group, predictions on the hazard of the
other substances in the group can be established. This paper discusses how
bioelution testing of metals and metal compounds can be used as an alternative to
animal testing for obtaining basic information on their potential toxicity, while
allowing compliance with strict information requirements. Two human health
hazard endpoints are used to illustrate how bioelution can become part of a
testing programme and in particular, target the requirement for new studies and
minimise the need for animal testing. In these cases, it is shown how
bioelution can be used to predict the hazard of several indium compounds as a first screening.