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J. D. Heidel, Z. Yu, J. Y. Liu, S. M. Rele, Y. Liang, R. K. Zeidan, D. J. Kornbrust and M. E. Davis, “Administration in Non-Human Primates of Escalating Intravenous Doses of Targeted Nanoparticles Containing Ribonucleotide Reductase Subunit M2 siRNA,” Proceedings of the National Academy of Sciences, Vol. 104, No. 14, 2007, pp. 5715- 5721. doi:10.1073/pnas.0701458104
has been cited by the following article:
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TITLE:
Reducible Poly (2-Dimethylaminoethyl) Methacrylate-Block-Polyvinylimidazole: Synthesis, Transfection Activity in Vitro
AUTHORS:
Bozhang Yu
KEYWORDS:
Reducible Polymer; Gene Expression; Transfection; Cytotoxicity
JOURNAL NAME:
Journal of Biomaterials and Nanobiotechnology,
Vol.3 No.1,
January
12,
2012
ABSTRACT: Reducible or imidazolyl polycations of block poly(imidazole/2-dimethyl aminoethyl) are of promising in gene delivery. Dimeric poly(2-dimethyl aminoethyl) methacrylate-block-polyvinylimidazole (rDPDMAEMAIM) and reducible poly (2-dimethylaminoethyl) methacrylate (rDPDMAEMA) with single disulfide bond in the backbone was synthesized by oxidizing their dithioester-terminated polymers. The polyplexes sizes, rDPDMAEMAIM/pDNA and rDPDMAEMA/ pDNA (plasmid DNA) are in the ranges of 100 nm - 150 nm at the weight ratio of 12:1, and the zeta potential of rDPDMAEMAIM/pDNA from 9.6 mV to 22.7 mV in PBS solutions increases with their weight ratios of 1:1 to 18:1. The results show that the rDPDMAEMAIM/pDNA polyplexes have higher transfection activity and lower cytotoxicity than that of rDPDMAEMAIM/pDNA against 293T cells in vitro in the presence of serum, indicating that the PDMAEMAIM present a promising nonviral gene vector.
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