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has been cited by the following article:

• TITLE: Photo-Induced DNA-Dependent Conformational Changes in Silver Nanoparticles

  AUTHORS: Vasil G. Bregadze, Zaza G. Melikishvili, Tamar G. Giorgadze

  KEYWORDS: Component; DNA-Silver Nanoparticle Complexes; Optical Spectroscopy of Intermolecular Interactions;Photo-Dynamic Effect; Silver Nanoparticles; Silver Ions

  JOURNAL NAME: Advances in Nanoparticles, Vol.2 No.2, May 27, 2013

  ABSTRACT: The goal of the present investigation is to study the interaction of AgNPs with thymus DNA by traditional and original spectra-photometric and thermo-dynamic methods and approaches in darkness and under photo-irradiation. 1) At the interaction of DNA with nano-particles hypsochromic shift of 6 nm and hypochromic effect of 20% of AgNPs absorption band are observed. 2) At photo-irradiation (λ = 436 nm or full spectrum of visible band) of AgNPs-DNA complexes absorption spectra band width is changed from 140 nm to 360 nm at half-height. Besides, isosbestic point is observed. 3) Kinetic study of photo-diffusion has made it possible to determine desorption rate constant and desorption reaction activation energy that are equal respectively to kd @ 9 ′ 10-5 s-1, Ed @ 80 kJ/M Ag0 for AgNPs bound with DNA. It is shown that AgNPs represent liquid drops which moisture the DNA surface at interaction. At photo-irradiation of AgNPs-DNA complex DNA dependant conformational transition takes place due to fast and intensive heating.