TITLE:
Serum Intestinal Fatty Acid Binding Protein in Patients with Small Bowel Obstruction
AUTHORS:
Kaoru Sakamoto, Tatsuo Kanda, Takeo Bamba, Hiroyuki Funaoka, Shin-ichi Kosugi, Kazuhito Yajima, Takashi Ishikawa
KEYWORDS:
Biomarker; I-FABP; Small Bowel Obstruction; Strangulation
JOURNAL NAME:
Surgical Science,
Vol.4 No.6,
May
30,
2013
ABSTRACT:
Purpose: The aims of this pilot study were to reveal the biological
characteristics of serum I-FABP and explore its clinical utility as a biomarker
in patients with small bowel obstruction (SBO). Methods: Serum I-FABP levels were measured in 37 consecutive
patients with SBO between 2007 and 2008. Serum I-FABP levels were compared
between ischemia (n = 10) and non-ischemia (n = 27) groups. Serum I-FABP levels
were longitudinally analyzed in 21 patients who showed high (>2.0 ng/ml)
serum I-FABP levels. The relationship between serum I-FABP level and length of
damaged bowel was also analyzed. Results: Median serum I-FABP levels were 9.2 ng/ml in the ischemia group and 1.9 ng/ml
in the non-ischemia group (p － 7.660, r
= 0.604, p = 0.0018). By setting the
cutoff level at 7.2 ng/ml, the diagnostic ability of serum I-FABP was 70.0% in
terms of sensitivity, 92.6% in terms of specificity, and 86.5% in terms of
accuracy. Conclusion: Serum I-FABP
sensitively reflects bowel damage in SBO patients and seems to be a potential
biomarker for detecting small-bowel ischemia.