TITLE:
Novel aspects of tRNA-derived small RNAs with potential impact in infectious diseases
AUTHORS:
Maria Rosa Garcia-Silva, Florencia Cabrera-Cabrera, Maria Catalina Güida, Alfonso Cayota
KEYWORDS:
Non-Coding RNAs; Small tRNAs; tRFs; tRNA Halves; Infectious Diseases
JOURNAL NAME:
Advances in Bioscience and Biotechnology,
Vol.4 No.5A,
May
27,
2013
ABSTRACT:
The complete understanding of
the growing catalog of regulatory non-coding RNAs is going to shed light in
different aspects of a wide range of pathogenic mechanisms in human diseases.
This review was aimed to highlight recent advances in the small non- coding RNA
world that could have implications in the development of new strategies in
medical sciences. Among the diverse group of small non-coding RNAs, we
highlight the group of tRNA-derived fragments as molecules known for a long
time which have recently emerged as novel regulators influencing several aspects
of cell biology. We describe here recent advances in the field of
tRNA-derived fragments playing key roles in the biology of some infectious
agents, including E. coli, A. fumigatus, G. lamblia, Ascaris, T. cruzi, Virus, Prions and a brief overview linking them
to cancer biology. Additionally, we focus on the potential implications of
these molecules in future biotechnological applications in the development of
new biomarkers and as new therapeutic targets.