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has been cited by the following article:

• TITLE: Effect of BDNF and Adipose Derived Stem Cells Transplantation on Cognitive Deficit in Alzheimer Model of Rats

  AUTHORS: Parvin Babaei, Bahram Soltani Tehrani

  KEYWORDS: Alzheimer’s Disease; Adipose Stem Cells; Brain-Derived Neurotrophic Factor; Learning and Memory

  JOURNAL NAME: Journal of Behavioral and Brain Science, Vol.3 No.1, March 6, 2013

  ABSTRACT: In this study, the potential for recovery mediated by co-treatment of brain-derived neurotrophic factor (BDNF) and adipose tissue derived stem cells (ASCs) on functional recovery after Ibotenic acid (Ibo) lesion of the nucleus basalis magnocellularis (NBM) was examined. Ibotenic acid was injected bilaterally into the NBM of experimental rats, then the animals received treatments as follows: ASCs (500 × 103), BDNF (5 ug/ul) and a combination of BDNF and ASCs. Two months after the treatment, cognitive recovery was assessed by the Morris water-maze. These results showed that ASCs transplantation may have therapeutic value in disease and conditions that result in memory loss, and co-treatment with BDNF doesn’t offer more efficacious cognitive function.