Effect of BDNF and Adipose Derived Stem Cells Transplantation on Cognitive Deficit in Alzheimer Model of Rats

Parvin Babaei, Bahram Soltani Tehrani

Cellular and Molecular Research Center, Guilan University of Medical Science, Rasht, Iran.
Department of Pharmacology, Guilan University of Medical science, Rasht, Iran.

DOI: 10.4236/jbbs.2013.31015                

Abstract

In this study, the potential for recovery mediated by co-treatment of brain-derived neurotrophic factor (BDNF) and adipose tissue derived stem cells (ASCs) on functional recovery after Ibotenic acid (Ibo) lesion of the nucleus basalis magnocellularis (NBM) was examined. Ibotenic acid was injected bilaterally into the NBM of experimental rats, then the animals received treatments as follows: ASCs (500 × 10³), BDNF (5 ug/ul) and a combination of BDNF and ASCs. Two months after the treatment, cognitive recovery was assessed by the Morris water-maze. These results showed that ASCs transplantation may have therapeutic value in disease and conditions that result in memory loss, and co-treatment with BDNF doesn’t offer more efficacious cognitive function.

Keywords

Alzheimer’s Disease; Adipose Stem Cells; Brain-Derived Neurotrophic Factor; Learning and Memory

Conflicts of Interest

The authors declare no conflicts of interest.

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