TITLE:
Effect of BDNF and Adipose Derived Stem Cells Transplantation on Cognitive Deficit in Alzheimer Model of Rats
AUTHORS:
Parvin Babaei, Bahram Soltani Tehrani
KEYWORDS:
Alzheimer’s Disease; Adipose Stem Cells; Brain-Derived Neurotrophic Factor; Learning and Memory
JOURNAL NAME:
Journal of Behavioral and Brain Science,
Vol.3 No.1,
March
6,
2013
ABSTRACT:
In this study, the potential for recovery
mediated by co-treatment of brain-derived neurotrophic factor (BDNF) and adipose
tissue derived stem cells (ASCs) on functional recovery after Ibotenic acid (Ibo) lesion of the nucleus
basalis magnocellularis (NBM) was examined. Ibotenic acid was injected bilaterally
into the NBM of experimental rats, then the animals received treatments as follows:
ASCs (500 × 103),
BDNF (5 ug/ul) and a combination of BDNF and ASCs. Two months after the treatment,
cognitive recovery was assessed by the Morris water-maze. These results showed that
ASCs transplantation may have therapeutic value in disease and conditions that result
in memory loss, and co-treatment with BDNF doesn’t offer more efficacious cognitive
function.