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S. M. Sherif, R. M. Mohareb, H. Z. Shams and H. M. Gaber, “A Convenient Synthesis of Polyfunctionally Substituted Benzo[b]thiophen-2-yl-pyrimidine,-pyrazole,-isoxazole and Pyridazine Derivatives,” Journal of Chemical Research, Vol. 1995, 1995, pp. 434-435, 2658-2674.
has been cited by the following article:
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TITLE:
The Reaction of Cyanoacetylhdrazine with Furan-2-Aldehyde: Novel Synthesis of Thiophene, Azole, Azine and Coumarin Derivatives and Their Antitumor Evaluation
AUTHORS:
Wagnat W. Wardakhan, Sherif M. Sherif, Rafat M. Mohareb, Amr S. Abouzied
KEYWORDS:
Acetylhydrazine; Hydrazide-Hydrazone; Thiophene; Thiazole; Pyridine; Coumarin; Antitumor
JOURNAL NAME:
International Journal of Organic Chemistry,
Vol.2 No.4,
December
27,
2012
ABSTRACT: The reaction of cyanoacetylhydrazine 1 with furan-2-aldehyde 2 gives the hydrazide-hydrazone derivative 3. The latter compound undergoes a series of heterocyclization reactions to give new heterocyclic compounds. The antitumor evaluation of the newly synthesized products against three cancer cell lines, namely breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and CNS cancer (SF-268) were recorded. Some of the synthesized compounds show high inhibitory effects.