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The Reaction of Cyanoacetylhdrazine with Furan-2-Aldehyde: Novel Synthesis of Thiophene, Azole, Azine and Coumarin Derivatives and Their Antitumor Evaluation

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DOI: 10.4236/ijoc.2012.24044    5,636 Downloads   9,867 Views   Citations


The reaction of cyanoacetylhydrazine 1 with furan-2-aldehyde 2 gives the hydrazide-hydrazone derivative 3. The latter compound undergoes a series of heterocyclization reactions to give new heterocyclic compounds. The antitumor evaluation of the newly synthesized products against three cancer cell lines, namely breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and CNS cancer (SF-268) were recorded. Some of the synthesized compounds show high inhibitory effects.

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The authors declare no conflicts of interest.

Cite this paper

W. Wardakhan, S. Sherif, R. Mohareb and A. Abouzied, "The Reaction of Cyanoacetylhdrazine with Furan-2-Aldehyde: Novel Synthesis of Thiophene, Azole, Azine and Coumarin Derivatives and Their Antitumor Evaluation," International Journal of Organic Chemistry, Vol. 2 No. 4, 2012, pp. 321-331. doi: 10.4236/ijoc.2012.24044.


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