TITLE:
The interaction between the dopaminergic and the serotonergic systems in the 6-OHDA rat model of Parkinson’s disease
AUTHORS:
Daphna Sourani, Gadi Goelman
KEYWORDS:
Parkinson’s Disease; Depression; 6-Hydroxydopamine; Lateral Habenula; Manganese-Enhanced-MRI
JOURNAL NAME:
Health,
Vol.4 No.11A,
November
29,
2012
ABSTRACT: This review summarizes published results that are related to the coupling between the dopaminergic and the serotonergic systems and their association to Parkinson’s disease. We focus on the 6-hydroxydopamine rat model of Parkinson’s disease to better understand how dopamine dysfunction affects the serotonergic system, and furthermore to investigate whether a bidi-rectional coupling exists and how it affects functionality and behavior. The accumulated evidence supports a proposed mechanism for this coupling that evolves the lateral habenula.