TITLE:
Facile Synthesis of Novel Chiral Bicyclic Thioureas and Their Crystal Structures
AUTHORS:
Ping An Wang, Hui Fang Nie, Lin Jie Yan, Sheng Yong Zhang
KEYWORDS:
Chiral Bicyclic Thiourea; cis-2, 5-Disubstituted Pyrrolidine; X-Ray Analysis
JOURNAL NAME:
International Journal of Organic Chemistry,
Vol.2 No.1,
March
15,
2012
ABSTRACT: The novel well-defined chiral bicyclic thioureas based on enantiopure unsymmetric cis-2,5-disustituted pyrrolidine skeleton were firstly synthesized and fully characterized by their 1H NMR, 13C NMR and HRMS. Their absolute configurations were also determined by single-crystal X-ray analysis.