Facile Synthesis of Novel Chiral Bicyclic Thioureas and Their Crystal Structures


The novel well-defined chiral bicyclic thioureas based on enantiopure unsymmetric cis-2,5-disustituted pyrrolidine skeleton were firstly synthesized and fully characterized by their 1H NMR, 13C NMR and HRMS. Their absolute configurations were also determined by single-crystal X-ray analysis.

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P. An Wang, H. Fang Nie, L. Jie Yan and S. Yong Zhang, "Facile Synthesis of Novel Chiral Bicyclic Thioureas and Their Crystal Structures," International Journal of Organic Chemistry, Vol. 2 No. 1, 2012, pp. 15-20. doi: 10.4236/ijoc.2012.21003.

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The authors declare no conflicts of interest.


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