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has been cited by the following article:

• TITLE: Radioiodination of Cephalexin with 125I and Its Biological Behavior in Mice

  AUTHORS: A.Abd El-Bary, A.M. Amin, A. El-wetery, S. Saad, M. Shoukry

  KEYWORDS: Cephalexin; Na125I; Electrophilic Substitution Reaction; Radioiodination; Inflammation

  JOURNAL NAME: Pharmacology & Pharmacy, Vol.3 No.1, January 12, 2012

  ABSTRACT: A procedure for radioiodination of Cephalexin with iodine-125 was carried out via an electrophilic substitution reaction. Using 3.7 MBq of Na125I, 200μl of cephalexin as substrate, 200 μl of iodogen as oxidizing agent in acetone at 40°C for 20 min, a maximum radiochemical yield of 125I-Ceph (95%) was obtained. The labeled compound was separated and purified by means of high-pressure liquid chromatography (HPLC). The biological distribution in normal and inflamed (septic and aseptic) mice indicates the suitability of radioiodinated cephalexin for imaging of inflammation