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https://doi.org/10.4236/oalib.1103987

has been cited by the following article:

• TITLE: Synthesis and Physico-Chemical Characterizations of Novel Hydrazone Ligands and Their Metal Complexes against Hormone-Dependent and Independent Cancers

  AUTHORS: Sommai Patitungkho, Kingkaew Patitungkho

  KEYWORDS: Metal Complexes, Cancers, Antioxidant, Hydrazone, Retinoid Receptors

  JOURNAL NAME: Open Journal of Medicinal Chemistry, Vol.14 No.1, March 29, 2024

  ABSTRACT: This work deals with the synthesis and physicochemical characterizations of a new group of novel retinoidal ligands and their metal complexes. Their in vitro anti-proliferative activities have shown that ligand L1 is effective against human breast cancer BT-20 and MCF-7 cell lines. At the same time, compound L2 exerts its effect on human prostate cancer PC-3 and human breast cancer MDA-MB-231 and MCF-7 cell lines respectively. The retinoid ligands exert their pleiotropic action toward retinoic acid receptors (RARs) than their metal complexes but all compounds exhibit concentration-dependent.