Czekay, R.-P., Wilkins-Port, C.E., Higgins, S.P., Freytag, J., Overstreet, J.M., Klein, R.M., Higgins, C.E., Samarakoon, R. and Higgins, P.J. (2011) PAI-1: An Integrator of Cell Signaling and Migration. International Journal of Cell Biology, 2011, Article ID: 562481. https://doi.org/10.1155/2011/562481

has been cited by the following article:

• TITLE: Potential of Natural Killer Cell Enriched Conditioned Media for Skin Care and Anti-Aging

  AUTHORS: Dong Soo Kim, Dong Ju Kim, Hyun Pyo Kim, Sung Hwan Hwang, Jung Hwa Kang

  KEYWORDS: Natural Killer Cell, NKEL, Skin Care, Wound Healing, Anti-Aging, KLKs, MMPs, EMT, Conditioned Media

  JOURNAL NAME: Journal of Cosmetics, Dermatological Sciences and Applications, Vol.11 No.2, June 8, 2021

  ABSTRACT: Natural killer (NK) cell is a type of immune cell and is known to be particularly responsible for innate immunity such as anti-cancer immunity, defense mechanisms against infections, and secretion of various cytokines and chemokines for increasing recruitment of other immune cells. In this study, we investigated the potentials of NK-enriched lymphocytes (NKEL) conditioned media (CM) on skin care for cosmeceutical compositions. Various cytokines of NKEL CM can improve wound healing through epithelial-mesenchymal transition (EMT) by increasing KLKs (kallikreins) and reduce metalloproteinase (MMP)-1 and MMP-2 to inhibit wrinkle formation. Our results suggest that NKEL CM which has various cytokines promotes up-regulation of cell migration and KLKs and down-regulation of MMP-1 and MMP-2 by stimulating HaCaT keratinocytes migration. Therefore, NKEL CM can be used as a cosmetic composition that can play a role in skin regeneration and anti-aging.