TITLE:
Advances in the Correlation between Intestinal Microbiota and Breast Cancer Development
AUTHORS:
Yonglan Jiang, Xinping Chen, Shengmiao Fu
KEYWORDS:
Breast Cancer, Microbial Dysbiosis, Estrogen Metabolism, Immune Response, Microbial Metabolism
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.11 No.12,
December
11,
2020
ABSTRACT: The intestinal microbiota has a symbiotic relationship
with humans. It participates in some important physiological activities in the human
body and has an important impact on human health. It has become a hot topic of research
by scientists in recent years. Among them, the research on the correlation between intestinal microbiota and cancer has
increased rapidly. At present, the incidence rate of breast cancer is
increasing, which seriously endangers the health of women. More and more
studies have found that the occurrence of breast cancer is related to
intestinal microbiota, and its possible mechanism includes intestinal
microbiota dysbiosis, estrogen metabolism changes, immune regulation, and the participation of intestinal microbiota
metabolites, etc. With the further development of high-throughput sequencing
technology, the research on the correlation between intestinal microbiota
and breast cancer has become more in-depth,
from a structural level confined to microorganisms to a more comprehensive
system structure and function level. These research results provide a new
research direction for the treatment of breast cancer. In order to further study
the interaction between intestinal microbes and breast cancer, this article
will comprehensively describe the intestinal microbiota and breast cancer from
four aspects: intestinal microbial dysbiosis, altered estrogen metabolism,
immune regulation, and intestinal microbial metabolites. It also reviews the
application research of intestinal microbiota in breast cancer treatment,
including the influence of intestinal microbiota on the effects of breast
cancer radiotherapy and chemotherapy, probiotic therapy, and dietotherapy.