TITLE:
The Impact of Obesity on Performing Lymphadenectomy and Its Outcome in Ovarian Cancer Patients
AUTHORS:
Basel Refky, Mosab Shetiwy, Ahmed Zaki, Mohamed Elmetwally, Hanan Nabil, Islam Abdou, Ahmed Abdallah, Amr Soliman, Khaled Abdelwahab, Anas Gamal, Essam Elshiekh, Khaled Gaballa
KEYWORDS:
Lymphadenectomy, Obesity, Ovarian Cancer
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.9 No.7,
July
23,
2018
ABSTRACT: Background: This study discusses the effect of obesity on the number of lymph nodes
harvested during systematic LND and the LND-related complications in ovarian
cancer patients. Methods: This retrospective study enrolled women with
ovarian cancer who were consecutively subjected to open surgical resection that
included systematic LND (pelvic and para-aortic) in the Oncology Center in
Mansoura University (OCMU) during the period between January 2012 and June 2017.
Patients were categorized according to the recommendations of World Health
Organization by their BMI as non-obese (BMI 30.0 kg/m2) and obese (BMI ≥ 30.0
kg/m2). Results: Seventy-seven women with ovarian cancer were
enrolled in the study according to our inclusion and exclusion criteria. 43
females (55.8%) were grouped as obese and 34 (44.2%) as non-obese. Lymph nodes
retrieved in total and in different stations separately (pelvic and
para-aortic) were all similar among patients in both groups. LND-related
intraoperative complications were observed in 8 patients (18.6%) in the obese
group and 3 patients in the non-obese group (8.8%) (P = 0.347). Hospital stay
was the same in the two groups with a median of 4 days (IQR 3 - 5). Postoperative
complications occurred in 13 patients (30.2%) in the obese group and only in
one patient (3%) in the non-obese group (P = 0.004). Conclusion: Obese
ovarian cancer patients may safely undergo comprehensive staging involving
extensive lymph node dissection in open surgeries without significant increase
in the rates of intraoperative complications. Whereas, postoperative
complications (wound infection and thromboembolic events) tend to occur at
higher rates with obese patients. Trial registration: This study was
retrospectively registered and approved at faculty of Medicine Mansoura
University, Egypt with IRB approval number R.18.02.46.