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has been cited by the following article:

• TITLE: Reactivity of 3-Cyanoacetylindole Derivatives: Synthesisof 3-Hydrazonopyrazolyl and 3-Thiadiazolyl Indole Derivatives

  AUTHORS: Hamdi M. Hassaneen, Huwaida M. E. Hassaneen, Zakaria Ahmed Gomaa

  KEYWORDS: 3-Methyl Indole, 3-Phenyl Indole, Phenyl Isothiocyanate, Cyanoacetic Acid

  JOURNAL NAME: International Journal of Organic Chemistry, Vol.1 No.3, September 28, 2011

  ABSTRACT: The coupling reaction of 3-cyanoacetyl-2-methylindole 1a with the aromatic diazonium salts gave the corresponding arylhydrazones 2a-e. Compounds 2 were used for synthesis of 4-aminopyrazole-5-carbonitrile 4a-e and 5-amino-4-arylazo-3-pyrazoles 5a-e derivatives. Also, treatment of 3-cyanoacetyl-2-phenylindole 1b with phenyl isothiocyanate gave the corresponding thioacetanilide 7. The later compound 7 was utilized as the key intermediate for the synthesis of some new thiadiazole derivatives 9a-r. The structures of all new compounds were elucidated on the basis of elemental analysis and spectral data.