Salar, U., Khan, K.M., Jabeen, A., Faheem, A., Fakhri, M.I., Saad, S.M., Perveen, S. and Taha, M. (2016) Coumarin Sulfonates: As Potential Leads for ROS Inhibition. Bioorganic Chemistry, 69, 37-47.
https://doi.org/10.1016/j.bioorg.2016.09.006

has been cited by the following article:

• TITLE: Coumarin and Biscoumarin Inhibit in Vitro Obesity Model

  AUTHORS: Farah Mukhtar, Kimberly Stieglitz, Shamsher Ali, Asma Ejaz, Muhammad Iqbal Choudhary, Muhammad Imran Fakhri, Uzma Salar, Khalid Mohammed Khan

  KEYWORDS: Coumarin, Sulphonated Coumarin, Biscoumarin, Adipocyte Differentiation and Docking Studies

  JOURNAL NAME: Advances in Biological Chemistry, Vol.6 No.5, October 28, 2016

  ABSTRACT: Coumarin, sulphonated coumarin, and biscoumarin compounds were examined for their effects on suppressing the adipocyte differentiation in 3T3-L1 cells. Many of them inhibited the adipocyte differentiation in a dose dependent manner, amongst them compounds (7), (28), and (33) significantly suppressed the adipogenic differenti-ation, and also exhibited lipolytic effect on mature adipocytes. The active compounds potentially imitate the AMP-activated protein kinase (AMPK) ligands, there- fore, binding of these compounds with AMPK possibly shuts down the anabolic pathways. Furthermore, these compounds were docked into binding pockets with reasonable pre-dicted binding constants in the low micromolar range. These results indicate that compounds (7), (28), and (33) inhibit adipogenic development in pre- adipocytes, having lipolytic effect on mature adipocytes, and can be potent activators of human AMPK.