Article citationsMore>>
Dure, K., Dubus, S., Ho, H.A., Levesque, I., Brunette, M., Corbeil, G., Boissinot, M., Boivin, G., Bergeron, M.G., Boudreau, D. and Leclerc, M. (2004) Fluorescent Polymeric Transducer for the Rapid, Simple, and Specific Detection of Nucleic Acids at the Zeptomole Level. Journal of the American Chemical Society, 126, 4240-4244.
http://dx.doi.org/10.1021/ja038900d
has been cited by the following article:
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TITLE:
New Approaches for the Use of Acetoacetanilide in the Synthesis of Thiophenes and Their Fused Derivatives with Anti-Tumor Activity
AUTHORS:
Rafat M. Mohareb, Sherif M. Sherif, Wagnat W. Wardakhan, Amr S. Abouzied
KEYWORDS:
Acetoaceanilide, Thiophene, Anti-Tumor, Docking
JOURNAL NAME:
Open Access Library Journal,
Vol.1 No.8,
November
26,
2014
ABSTRACT: Acetoacetanilide derivatives 1a-c reacted with either malnonitrile or ethyl cyanoacetate and elemental sulfur to give the thiophene derivatives 3a-f. The reactivity of 3a towards some chemical reagents to give thiophene, theino[2,3-b]pyridine, thieno[2,3-c]pyrimidine and coumarin derivatives was studied. The anti-tumor evaluation of the newly synthesized compounds against the three human tumor cells lines namely breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and CNS cancer (SF-268) showed that compounds 8a, 8b and 14 exhibit higher inhibitory effects towards the three tumor cell lines than the positive control doxorubicin.
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