TITLE:
Homeostatic Conductance and Parasympathetic Basis Alteration: Two Alternative Approaches to Deep Brain Stimulation in Parkinson’s, Obsessive Compulsive Disorder and Depression
AUTHORS:
Richard Lawrence Norman
KEYWORDS:
Deep-Brain-Stimulation, Obsessive-Compulsive-Disorder, Depression, Parkinson’s, Hippocampus
JOURNAL NAME:
World Journal of Neuroscience,
Vol.6 No.1,
February
26,
2016
ABSTRACT: Derived through the dual
focus of psychology and neuroscience, disciplines such as Affective
Neuroscience and Neuropsychoanalysis may offer new directions of approach to
many pathologies, which demonstrate psychical and somatic etiology. Insights
gained from these two trustworthy yet still peripheral scientific disciplines,
are deserving of consideration and exploration. It is the purpose of this paper
to offer up several such possible new avenues of exploration, as they relate to
depression, Obsessive Compulsive Disorder (OCD), and Parkinson’s Disease (PD).
The basic therapeutic focus in deriving these proposed new clinical approaches
is twofold: 1) Deep Brain Stimulation (DBS) and 2) Mnemic alteration via
neuropeptide assisted therapy producing positive relative adjustment in the
balance of basic sympathetic (dopaminergic) and parasympathetic affective
circuitry independent of drugs or surgery. New conductance level and target
strategies designed to prevent homeostatic degeneration are advanced under the
concept ofhomeostaticconductance. New electrical
stimulation targets are suggested, which restore basic rhythmic balance between
pathologically affected and unaffected brain areas. In this way, we offer up
new directions for research, strategies for noninvasive and nontoxic potential
therapies and new targets/ approaches to DBS therapy.