TITLE:
Change of Erythrocytes Transport Function in Blood of Men with Prostate Adenocarcinoma (before and after Plastic Orchiectomy)
AUTHORS:
Manana Alibegashvili, Nato Veshapidze, Liana Ramishvili, Manana Gordeziani, Teimuraz Chigogidze, Nino Gabunia, Ana Khazaradze, Nanuli Kotrikadze
KEYWORDS:
Prostate Tumors, Plastic Orchiectomy, Na+/Ka+-ATP-ase
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.6 No.15,
December
23,
2015
ABSTRACT: The changes of blood
erythrocytes transport function in patients with prostate adenocarcinoma have
been studied according to alterations in Na+/K+-ATP-ase
activity and permeability of Na+ and K+ ions, before and
after the plastic orchiectomy. The results of the study revealed that activity
of Na+/K+-ATP-ase was increased compared with the data
before the orchiectomy, but this parameter was reduced compared with control
group. The increased amounts of the Na+ as well as K+ ions were also observed in the extracellular area compared with the same data
before the orchiectomy. The amount of cholesterol, after plastic orchiectomy,
was reduced compared with the data gained before orchiectomy, but the data were
greater than those of the control group. It may be presumed that one of the
reasons for change of Na+/K+-ATP-ase activity is
variation of cholesterol content in erythrocyte membrane. Changes of the active
transport system, in turn, affect the transport function of the erythrocyte
membrane. In spite of surgical intervention, full recovery of patients does not
take place after the plastic orchiectomy. Comparative normalization and
approaching to the control group of the given indices in post-operation period
(~6 months after surgery) indicate strengthening of the immune system and
correspondingly—protective abilities of an organism, which was
proved by the anamneses of patients.