Himmler, A., Drechsel, D., Kirschner, M.W. and Martin, D.W. (1989) Tau Consists of a Set of Proteins with Repeated C-Terminal Microtubule-Binding Domains and Variable N-Terminal Domains. Molecular and Cellular Biology, 9, 1381-1388.

has been cited by the following article:

• TITLE: The Drug Development Based on Pathogenetic Research in Alzheimer’s Disease

  AUTHORS: Xiaoqian Lin, Qingzhu Zhang

  KEYWORDS: Alzheimer’s Disease, Aβ, Protein Tau, ULMWH, MT-Stabilizing Agents

  JOURNAL NAME: Advances in Alzheimer's Disease, Vol.3 No.2, June 16, 2014

  ABSTRACT: Neuropathologically, Alzheimer’s disease is characterized by the presence of extracellular deposits of amyloid-β peptides, intracellular neurofibrillary tangles and atrophy of the basal forebrain cholinergic neurons. The research of pathogenesis of Alzheimer’s disease inspirits potential clinical drugs for treatment. To block the progression of the disease, drugs under development have to interfere with the pathogenic steps responsible for the clinical symptoms, including cholinergic deficit, calcium dysregulation, inflammation and oxidative damage, and the deposition of amyloid- β plaques and of neurofibrillary tangles. In this review, the pertinent literature about drugs targeted on relieving symptoms above is reviewed. We aim to discuss possible research priorities in the future.