TITLE:
Amino acid profiles in relation to chronic periodontitis and rheumatoid arthritis
AUTHORS:
Tetsuo Kobayashi, Moe Okada, Satoshi Ito, Daisuke Kobayashi, Atsuko Shinhara, Takahiko Muramatsu, Tsuyoshi Kobayashi, Ichiei Narita, Kiyoshi Nakazono, Akira Murasawa, Hiromasa Yoshie
KEYWORDS:
Amino Acid; Chronic Periodontitis; Rheumatoid Arthritis; Case-Control Study
JOURNAL NAME:
Open Journal of Stomatology,
Vol.4 No.2,
February
18,
2014
ABSTRACT: Chronic periodontitis (CP) and rheumatoid
arthritis (RA) are chronic inflammatory conditions, and share many pathologic
features. Plasma amino acid profiles have been shown to be associated with RA,
but their relevance to CP remains unclear. The aim of the present study is to
evaluate amino acid profiles in relation to CP and RA. The study participants
consisted of 62 patients with RA (RA group), 30 patients with CP (CP group) and
29 healthy controls (H group) in age-, gender-, smoking status-balanced
condition. Clinical periodontal and rheumatologic parameter values and plasma
levels of 21 amino acids, C-reactive protein (CRP), interleukin-6 (IL-6), and
tumor necrosis factor-alpha (TNF-α)
were determined. Multiple comparison analyses revealed that the RA group
exhibited similar periodontal conditions but significantly higher levels of
CRP, IL-6, and TNF-α than the CP
group (P P P P P = 0.006) in the RA group. These
results suggest a possibility that profiles of four amino acids may play a role
in the pathogenesis of CP and RA.