TITLE:
Hepcidin Prohormone Levels in Patients with Primary Open-Angle Glaucoma
AUTHORS:
Asaad A. Ghanem, Salah E. Mady, Tarek N. Attia, Lamiaa F. Arafa
KEYWORDS:
Hepcidin Prohormone; Aqueous Humor; POAG; Cataract
JOURNAL NAME:
Open Journal of Ophthalmology,
Vol.4 No.1,
February
13,
2014
ABSTRACT:
Aims: To assess the levels of hepcidin prohormone (Hep)
in aqueous humor and plasma of human eyes with primary open-angle glaucoma
(POAG) and to correlate their concentrations with the severity of glaucoma. Methods: Sixty patients with POAG and
forty five patients with senile cataract (control group) were enrolled in the
study prospectively. Aqueous humor samples were obtained by paracentesis from
glaucoma and cataract patients who were undergoing elective surgery. Aqueous
humor andcorresponding plasma samples were analyzed for Hep concentrations
by enzyme-linked immunosorbent assay. Results:
Hep levels were significantly lower in aqueous humor of POAG patients with
respect to the comparative group of cataract patients (P