N. Umigai, K. Murakami, M. V. Ulit, L. S. Antonio, M. Shirotori, H. Morikawa and T. Nakano, “The Pharmacokinetic Profile of Crocetin in Healthy Adult Human Volunteers after a Single Oral Administration,” Phytomedicine, Vol. 18, No. 7, 2011, pp. 575-578.
http://dx.doi.org/10.1016/j.phymed.2010.10.019

has been cited by the following article:

• TITLE: Crocetin Prevents Amyloid β1-42-Induced Cell Death in Murine Hippocampal Cells

  AUTHORS: Yuta Yoshino, Mitsue Ishisaka, Naofumi Umigai, Masamitsu Shimazawa, Kazuhiro Tsuruma, Hideaki Hara

  KEYWORDS: Alzheimer’s Disease; Amyloid β1-42; Crocetin; HT22; Oxidative Stress

  JOURNAL NAME: Pharmacology & Pharmacy, Vol.5 No.1, January 13, 2014

  ABSTRACT: Crocetin is an aglycon of carotenoid extracted by saffron stigmas (Crocus sativus L.) and known to have a potent anti-oxidative effect. Amyliod β (Aβ), hallmark of Alzheimer’s disease, is reported to have neurotoxicity partly via oxidative stress. In this study, we investigated the effect of crocetin on hippocampal HT22 cell death induced by Aβ1-42. Furthermore, to clarify the mechanism underlying the protective effects of crocetin against Aβ1-42- induced cell death, we measured reactive oxygen species (ROS) production by CM-H2DCFDA kit assay. Crocetin at 1 -10 μM protected HT22 cells against Aβ1-42-induced neuronal cell death and decreased ROS production increased by Aβ1-42. These results that crocetin has the potent neuroprotective effect against Aβ1-42-induced cytotoxicity in hippocampal cells by attenuating oxidative stress, suggest that crocetin may provide a useful therapeutic strategy against Aβ-related disorders.