TITLE:
Biopolymer Sponge for High Grade Renal Trauma: An Experimental Study in Rabbits
AUTHORS:
Leandro H. M. Tavares, Fábio O. Vilar, José L. Aguiar, Alexandre R. Paz, Francisco A. D. Melo, Gustavo R. P. Negromonte
KEYWORDS:
Acute Renal Injury; Surgical Hemostasis; Absorbable Implants; Inflammation; Biocompatible Materials
JOURNAL NAME:
Open Journal of Urology,
Vol.4 No.1,
January
7,
2014
ABSTRACT:
Introduction: Acute blunt or open renal trauma
sometimes requires conservative measure which involves
the use of specific materials in order to adequately restore renal parenchima.
The purpose of this study is to analyze the effects of the sugar cane
biopolymer sponge in an experimental model of renal trauma in rabbits. Methods: Experimental prospective
study was paired with
twelve New Zealand rabbits. After induction of renal trauma bilateral
high-grade (grade 4-collecting system, according to AAST), the sugar cane
biopolymer sponge was used for homeostasis and reconstruction of the right renal
parenchyma (experimental group). The same procedure was performed in the left kidney,
but using the Surgifoam? sponge (Control Group). The animals were
sacrificed after four weeks. Histological analysis was performed and the
results were compared after
statistically being evaluated.
Results: Comparing the
experimental group with the control, there was more inflammatory reaction and
premature adhesions in the first one. Concerning the influence on efficacy and
biocompatibility of the biopolymer, no serious complications like massive bleeding, haematoma, fistula
or urinary stone formation were found in both groups. Conclusion: The sugar cane biopolymer sponge demonstrated good
efficacy in relation to hemostatic control and reconstruction of the renal
parenchyma without major complications. Future studies may direct its routine
use in urologic practice.