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has been cited by the following article:

• TITLE: Isolated aldosterone deficiency in two infants: Mistakes and dilemmas in the diagnosis and treatment of a rare disease

  AUTHORS: Ivana Pela, Laura Capirchio, Camilla Menchini, Giulia Anzilotti, Salvatore Seminara

  KEYWORDS: Hyponatremia; Salt-Wasting Syndrome; Metabolic Acidosis; Aldosterone; Renin

  JOURNAL NAME: Open Journal of Pediatrics, Vol.3 No.4, December 12, 2013

  ABSTRACT: In this article, we describe the clinical picture and follow-up of two children diagnosed as suffering from pseudohypoaldosteronism when they were infants, and it was later recognized as isolated aldosterone deficiency in both. We illustrate the clinical differences between the two patients in terms of hydroelectrolytic balance, laboratory data and growth. In fact, while the growth and hematological parameters of the electrolytes and acid-base balance were normal in the first patient, and also without treatment with fludrocortisone thanks to very high renin activity, in the second patient, this treatment was vitally necessary to maintain normal growth and biochemical data. Despite the absence of a molecular analysis which could have confirmed this diagnosis, we believe that the description of the clinical evolution of these two cases from the moment of the incorrect diagnosis until the correct diagnosis and action taken, could be useful to highlight the extreme clinical variability of this rare disease.