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has been cited by the following article:

• TITLE: Systemic Inflammation in Patients with Chronic Obstructive Pulmonary Disease: Results from the Cosmic Study

  AUTHORS: Marie-Kathrin Breyer, Eric P. A. Rutten, Martijn A. Spruit, Wim C. J. Hop, Dirkje S. Postma, Emiel F. M. Wouters

  KEYWORDS: Adipokines; Body Composition; CRP, Fibrinogen; Obesity; TNFα

  JOURNAL NAME: Open Journal of Respiratory Diseases, Vol.2 No.3, August 10, 2012

  ABSTRACT: Objective: The study aims to elucidate the association of host-related factors on systemic inflammation in COPD patients. Methods: In 295 clinically stable and optimally treated COPD patients from 39 outpatient centers, age, gender, and body composition (body mass index, BMI; fat-free mass index, FFMI; fat mass index, FMI) were related to inflammatory biomarkers: CRP, fibrinogen, TNFα, and its soluble receptors (s)TNFαR1 and sTNFαR2. Furthermore, forced expiratory volume in the first second (FEV1), BMI, FFMI, and FMI were stratified by quartiles to elucidate the influence on inflammatory biomarkers. Monovariate and multivariate regression analyses were performed for associations between inflammatory biomarkers. Results: Positive correlations were found for FFMI with sTNFαR1, FMI with CRP and age with TNFα, sTNFαR1 and sTNFαR2 (p