Evaluation of a Plasma hCG Method for Point of Care Testing with the Aim of Shortening Test-Turnaround-Times ()
Anna-Karin Wikström1,
Magnus Hagmar1,
Göran Ronquist2,
Anders Larsson2*
1Department of Women’s and Children’s Health, Uppsala University, Uppsala, Sweden.
2Department of Medical Sciences, Section of Clinical Chemistry, Uppsala University, Uppsala, Sweden.
DOI: 10.4236/ojog.2015.56049
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Abstract
Objective: To examine the correlation between plasma hCG results obtained
with the new i-STAT® hCG point of care test with those concomitantly
obtained from the central hospital laboratory utilizing the same patient
samples. Methods: Prospective
cross-sectional laboratory test evaluation. We compared plasma hCG results
obtained with the i-STAT® hCG test (Abbott Point of Care, Princeton, NJ,
USA) with Architect Ci8200 (Abbott Laboratories, Abbott Park, IL, USA). We also
calculated the total coefficient of variation (CV) for the i-STAT® method.
Results: The two methods showed
a good linear correlation (R2 = 0.994; slope 1.03) and CV for the
i-STAT® method was 2.1% - 5.2%. Conclusion:
We suggest that the i-STAT® hCG blood assay could be used as a complement
to urine hCG assays in clinical situations when rapid test results are needed
and urine is not available.
Share and Cite:
Wikström, A. , Hagmar, M. , Ronquist, G. and Larsson, A. (2015) Evaluation of a Plasma hCG Method for Point of Care Testing with the Aim of Shortening Test-Turnaround-Times.
Open Journal of Obstetrics and Gynecology,
5, 341-343. doi:
10.4236/ojog.2015.56049.
Conflicts of Interest
The authors declare no conflicts of interest.
References
[1]
|
Vaitukaitis, J.L. (2004) Development of the Home Pregnancy Test. Annals of the New York Academy of Sciences, 1038, 220-222. http://dx.doi.org/10.1196/annals.1315.030
|
[2]
|
Cacciatore, B., Stenman, U.H. and Ylostalo, P. (1990) Diagnosis of Ectopic Pregnancy by Vaginal Ultrasonography in Combination with a Discriminatory Serum hCG Level of 1000 IU/l (IRP). British Journal of Obstetrics and Gynaecology, 97, 904-908. http://dx.doi.org/10.1111/j.1471-0528.1990.tb02445.x
|
[3]
|
Gronowski, A.M., Powers, M., Stenman, U.H., Ashby, L. and Scott, M.G. (2009) False-Negative Results from Point-of-Care Qualitative Human Chorionic Gonadotropin (hCG) Devices Caused by Excess hCGbeta Core Fragment Vary with Device Lot Number. Clinical Chemistry, 55, 1885-1886. http://dx.doi.org/10.1373/clinchem.2009.133280
|