Clinical characteristics and coronary features of coronary ectasia and aneurysm in China

DOI: 10.4236/wjcd.2013.31005   PDF   HTML   XML   4,009 Downloads   6,413 Views   Citations


Objective: To describe the clinical characteristics and coronary features of patients with coronary ectasia and aneurysm (CEA) in China. Methods: This was a single center, retrospective clinical study. Patients with CEA who diagnosed by coronary artery angiography (CAG) from April 2003 to October 2009, were enrolled. All patients were followed up by the call or clinic visit. The primary outcome was all-cause mortality or cardiovascular readmission. Results: A total of 39 patients (27 male, mean age 59.5 ± 12.6 years) diagnosed with CEA, with a prevalence of 0.6% (a total of 6,130 patients underwent CAG during the same period). Thirty-six patients constituted the study population, due to 3 patients lost of follow-up. The median follow-up was 27 months (1 - 76). The single vessel was involved in 11 patients (31%), two vessels were involved in 14 patients (38%) and three or more vessels were involved in 11 patients (31%). The most common involved vessel was left anterior descending branch (n = 27), followed by right coronary artery (n = 23), left circumflex branch (n = 20) and left main branch (n = 9). There was no death during the follow-up. The primary outcome was observed in 8 (22%) patients. The use of clopidogrel and statins were associated with lower rate of cardiovascular readmission. Conclusion The incidence of CEA was low among patients who referred for CAG in China. The majority of patients had the involvement of multiple vessels, and left anterior descending branch was the most common involved vessel. The CEA patients may benefit from clopidogrel and statins.

Share and Cite:

Cheng, Z. , Liu, Y. , Zhang, S. , Wu, W. , Shen, Z. , Fan, Z. , Xie, H. , Liu, Z. , Jin, X. , Wang, C. , Zeng, Y. and Fang, Q. (2013) Clinical characteristics and coronary features of coronary ectasia and aneurysm in China. World Journal of Cardiovascular Diseases, 3, 18-21. doi: 10.4236/wjcd.2013.31005.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] Hartnell, G.G., Parnell, B.M. and Pridie, R.B. (1985) Coronary artery ectasia. Its prevalence and clinical significance in 4993 patients. British Heart Journal, 54, 392-395. doi:10.1136/hrt.54.4.392
[2] Sway, P.S., Fisher, L.D., Litwin, P., Vignola, P.A., Jud- kins, M.P., Kemp, H.G., Mudd, J.G. and Gosselin, A.J. (1983) Aneurysmal coronary artery disease. Circulation, 67, 134-138. doi:10.1161/01.CIR.67.1.134
[3] Lam, C.S. and Ho, K.T. (2004) Coronary artery ectasia: A ten-year experience in a tertiary hospital in Singapore. Annals, Academy of Medicine, Singapore, 33, 419-422.
[4] Demopoulos, V.P., Olympios, C.D., Fakiolas, C.N., Pissi- missis, E.G., Economides, N.M., Adamopoulou, E., Foussas, S.G. and Cokkinos, D.V. (1997) The natural history of aneurysmal coronary artery disease. Heart, 78, 136-141.
[5] Baman, T.S., Cole, J.H., Devireddy, C.M. and Sperling, L.S. (2004) Risk factors and outcomes in patients with coronary artery aneurysms. American Journal of Cardiology, 93, 1549-1551. doi:10.1016/j.amjcard.2004.03.011
[6] Maehara, A., Mintz, G.S., Ahmed, J.M., et al. (2001) An intravascular ultrasound classification of angiographic coronary artery aneurysms. American Journal of Cardiology, 88, 365-370. doi:10.1016/S0002-9149(01)01680-0
[7] Markis, J.E., Joffe, C.D., Cohn, P.F., Feen, D.J., Herman, M.V. and Gorlin, R. (1976) Clinical significance of coronary arterial ectasia. American Journal of Cardiology, 37, 217-222. doi:10.1016/0002-9149(76)90315-5
[8] Mariscalco, G., Mantovani, V., Ferrarese, S., Leva, C., Orru, A. and Sala, A. (2006) Coronary artery aneurysm: Management and association with abdominal aortic aneurysm. Cardiovascular Pathology, 15, 100-104. doi:10.1016/j.carpath.2005.11.005
[9] Cohen, P. and O’Gara, P.T. (2008) Coronary artery an- eurysms: A review of the natural history, pathophysiol- ogy, and management. Cardiology in Review, 16, 301- 304. doi:10.1097/CRD.0b013e3181852659
[10] Yetkin, E. and Waltenberger, J. (2007) Novel insights into an old controversy: Is coronary artery ectasia a variant of coronary atherosclerosis? Clinical Research in Cardiol- ogy, 96, 331-339. doi:10.1007/s00392-007-0521-0
[11] Krüger, D., Stierle, U., Herrmann, G., Simon, R. and Sheik-hzadeh, A. (1999) Exercise-induced myocardial ischemia in isolated coronary artery ectasias and aneurysms (“dilated coronopathy”). Journal of the American College of Cardiology, 34, 1461-1470. doi:10.1016/S0735-1097(99)00375-7
[12] Akyurek, O., Berkalp, B., Sayin, T., Kumbasar, D., Ker- vancio?lu, C. and Oral, D. (2003) Altered coronary flow properties in diffuse coronary artery ectasia. American Heart Journal, 145, 66-72. doi:10.1067/mhj.2003.48
[13] Aboud, A., Bossert. T., Sigusch, H.H. and Gummert, J. (2007) Surgical treatment of multiple atherosclerotic coronary artery aneurysms in a patient with acute myocardial infarction. Clinical Research in Cardiology, 96, 45-48. doi:10.1007/s00392-006-0453-0
[14] Rath, S., Har-Zahav, Y., Battler, A., Agranat, O., Rotstein, Z., Rabinowitz, B. and Neufeld, H.N. (1985) Fate of no-nobstructive aneurysmatic coronary artery disease: An- giographic and clinical follow-up report. American Heart Journal, 109, 785-791. doi:10.1016/0002-8703(85)90639-8
[15] Alloul, S., Dahdah, N. and Miró, J. (2009) Thrombus in a coronary artery aneurysm shortly after warfarin withdrawal. Pediatric Cardiology, 30, 188-190. doi:10.1007/s00246-008-9290-4
[16] Turhan, H. and Yetkin, E. (2007) What is the plausible strategy for the management of patients with isolated coronary artery ectasia and myocardial ischemia? International Journal of Cardiology, 117, 285-286. doi:10.1016/j.ijcard.2006.05.042
[17] Tokgozoglu, L., Ergene, O., Kinay, O., Nazli, C., Hasce-lik, G. and Hoscan, Y. (2004) Plasma interleukin-6 levels are increased in coronary artery ectasia. Acta Cardiologica, 59, 515-519. doi:10.2143/AC.59.5.2005226
[18] Ozbay, Y., Akbulut, M., Balin, M., Kayancicek, H., Bay- das, A. and Korkmaz, H. (2007) The level of hs-CRP in coronary artery ectasia and its response to statin and angiotensinconverting enzyme inhibitor treatment. Media- tors of Inflammation, 2007, 89649. doi:10.1155/2007/89649
[19] Aronow, W.S. (2011) Peripheral arterial disease and abdominal aortic aneurysm in elderly people. Minerva Medica, 102, 483-500.
[20] Saratzis, A., Saratzis, N., Melas, N. and Kiskinis, D. (2008) Pharmacotherapy before and after endovascular repair of abdominal aortic aneurysms. Current Vascular Pharmacology, 6, 240-249. doi:10.2174/157016108785909689

comments powered by Disqus

Copyright © 2020 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.