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Insights on the structural characteristics of NDM-1: The journey so far

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DOI: 10.4236/abc.2012.24040    5,729 Downloads   11,120 Views   Citations

ABSTRACT

New Delhi metallo-β-lactamase (NDM-1) has created a medical storm ever since it was first reported; as it is active on virtually all clinically used β-lactam antibiotics. NDM-1 rampancy worldwide is now considered a nightmare scenario, particularly due to its rapid dissemination. An underlying theme in the majority of recent studies is structural characterization as knowledge of the three-dimensional structure of NDM-1 shall help find connections between its structure and function. Moreover, structural details are even critical in order to reveal the resistance mecha- nism to β-lactam antibiotics. In this perspective, we review structural characteristics of NDM-1 that have been delineated since its first report. We anticipate that these structure-function connections made by its characterization shall further serve as future guidelines for elucidating pathways towards de novo design of functional inhibitors.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Saini, A. and Bansal, R. (2012) Insights on the structural characteristics of NDM-1: The journey so far. Advances in Biological Chemistry, 2, 323-334. doi: 10.4236/abc.2012.24040.

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