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Kumarasamy, K.K., Toleman, M.A., Walsh, T.R., Bagaria, J., Butt, F., Balakrishnan, R., Chaudhary, U., Doumith, M., Giske, C.G., Irfan, S., Krishnan, P., Kumar, A.V., Maharajan, S., Mushtaq, S., Noorie, T., Paterson, D.L., Pearson, A., Perry, C., Pike, R., Rao, B., Ray, U., Sarma, J.B., Sharma, M., Sheridan, E., Thirunarayan, M.A., Turton, J., Upadhay, S., Warner, M., Welfare, W., Livermore, D.M. and Woodford, N. (2010) Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: A mole
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TITLE:
Insights on the structural characteristics of NDM-1: The journey so far
AUTHORS:
Avneet Saini, Rohit Bansal
KEYWORDS:
NDM-1; Metallo-β-Lactamase; Superbug; β-Lactam; Extended-Spectrum β-Lactamases
JOURNAL NAME:
Advances in Biological Chemistry,
Vol.2 No.4,
November
21,
2012
ABSTRACT: New Delhi metallo-β-lactamase (NDM-1) has created a medical storm ever since it was first reported; as it is active on virtually all clinically used β-lactam antibiotics. NDM-1 rampancy worldwide is now considered a nightmare scenario, particularly due to its rapid dissemination. An underlying theme in the majority of recent studies is structural characterization as knowledge of the three-dimensional structure of NDM-1 shall help find connections between its structure and function. Moreover, structural details are even critical in order to reveal the resistance mecha- nism to β-lactam antibiotics. In this perspective, we review structural characteristics of NDM-1 that have been delineated since its first report. We anticipate that these structure-function connections made by its characterization shall further serve as future guidelines for elucidating pathways towards de novo design of functional inhibitors.
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