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Tolerability of a Proprietary Larch Arabinogalactan Extract: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial in Healthy Subjects

Abstract Full-Text HTML Download Download as PDF (Size:192KB) PP. 1533-1538
DOI: 10.4236/fns.2012.311200    3,745 Downloads   5,930 Views   Citations
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Barbara Grube, Heike Stier, Linda Riede, Joerg Gruenwald


Analyze & Realize ag, Waldseeweg 6, 13467 Berlin, Germany..
Kurfürstendamm 157/158, 10709 Berlin, Germany.


In a placebo-controlled, double-blind, randomized clinical trial, the tolerability of a proprietary larch arabinogalactan preparation (ResistAidTM) was investigated. METHODS: 199 healthy participants were randomly assigned to receive either placebo (n = 98) or an arabinogalactan preparation (n = 101) over a period of 12 weeks. As safety parameters the total number of adverse events, changes in various biochemical and laboratory parameters as well as the global evaluation of tolerability by investigator and subjects compared to placebo were evaluated. RESULTS: In total 16 adverse events were observed in 16 subjects, with no difference between the arabinogalactan and the placebo group (p = 0.935). There were no differences in the mean changes of the measured biochemical and laboratory parameters. The tolerability of the arabinogalactan extract was rated as “very good” or “good” by the investigators for 99% of the subjects and by 98% subjects in self-assessment with no statistical differences to placebo. CONCLUSION: The measured parameters as well as the evaluation of the tolerability by the investigators and the subjects demonstrate a very good tolerance profile of the proprietary arabinogalactan extract with no differences to placebo when taken for 12 weeks.


Randomized Placebo-Controlled Study; Proprietary Larch Arabinogalactan; Safety; Tolerability; Resist AidTM

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B. Grube, H. Stier, L. Riede and J. Gruenwald, "Tolerability of a Proprietary Larch Arabinogalactan Extract: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial in Healthy Subjects," Food and Nutrition Sciences, Vol. 3 No. 11, 2012, pp. 1533-1538. doi: 10.4236/fns.2012.311200.

Conflicts of Interest

The authors declare no conflicts of interest.


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