Author(s)

Miki Goto¹, Hiroshi Mizuma¹, Yasuhiro Wada¹, Masaaki Suzuki², Yasuyoshi Watanabe¹, Hirotaka Onoe^1*, Hisashi Doi^1*

¹Division of Bio-Function Dynamics Imaging, RIKEN Center for Life Science Technologies (CLST), Kobe, Japan.
²National Center for Geriatrics and Gerontology, Obu, Japan.

Synthesis of ¹¹C-labeled capsaicin ([¹¹C]-2) was accomplished by O-[¹¹C]methylation with [¹¹C]-methyl iodide to a corresponding catechol precursor (1). In Vivo whole-body distribution of [¹¹C]-2 in rats was investigated by positron emission tomography after intravenous injection. The results showed that [¹¹C]-2 accumulated in the brain and body surface, which was closely associated with the expression of transient receptor potential vanilloid 1.

PET, Capsaicin, ¹¹C-Labeling, TRPV1, Blood-Brain Barrier

Goto, M. , Mizuma, H. , Wada, Y. , Suzuki, M. , Watanabe, Y. , Onoe, H. and Doi, H. (2015) ¹¹C-Labeled Capsaicin and Its in Vivo Molecular Imaging in Rats by Positron Emission Tomography. Food and Nutrition Sciences, 6, 216-220. doi: 10.4236/fns.2015.62022.