Open Journal of Medicinal Chemistry
Volume 3, Issue 1 (March 2013)
ISSN Print: 2164-3121 ISSN Online: 2164-313X
Google-based Impact Factor: 0.71 Citations
Identification of HCV Inhibitors from a Cell-Based Sub-Genomic Replicon Screen ()
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ABSTRACT
A high throughput screen of the Pfizer compound collection was carried out using a hepatitis C virus (HCV) genotype 1b subgenomic replicon cell line. Those confirmed hits that demonstrated broad spectrum activity without overt cytotoxicity were further evaluated, leading to the identification of a series of pyrrolopyridines with excellent antiviral activity in a fully infectious HCV cell-based assay and pharmacokinetic properties.
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