Author(s)

Coulibaly Bamoro^1,2, Fante Bamba^1*, Koffi Téki Dindet Steve-Evanes², Vallin Aurélie², Chagnault Vincent²

¹Laboratoire de Constitution et Réaction de la Matière, Université Félix Houphouët-Boigny, Abidjan, Cote d’Ivoire.
²Laboratoire de Glycochimie, des Antimicrobiens et des Agroressources (LG2A), UMR 7378 CNRS, Université de Picardie Jules Verne, Amiens, France.

Due to the continuous emergence and rapid spread of drug-resistant strains of bacteria, there is an urgent need for the development of novel antimicrobials. Along this line, the synthesis and antibacterial activity of 4,5-diphenylimidazol-2-thiol derivatives 2a-g and 6a-e are reported. The structures of the synthesized compounds were confirmed by Nuclear Magnetic Resonance (NMR) and High Resolution Mass Spectrometry (HRMS). All compounds were screened in vitro for their antibacterial activity against Pseudomonas aeruginosa and Escherichia coli (Gram-negative bacteria) and also against Staphyloccocus aureus and Enterococcus faecalis (Gram-positive bacteria). The results showed most of the synthesized compounds have no antibacterial activity. However compound 6d was two-fold potent than ciprofloxacin against Staphylococcus aureus with Minimum Inhibitory Concentration (MIC) of 4 μg/mL and 6c showed moderate biological activity against Staphylococcus aureus (16 μg/mL) and Enterococcus faecalis (16 μg/mL).

Synthesis, 4,5-diphenylimidazole-2-thiol, Benzimidazole, Antibacterial Activity, Drug-Resistant

Bamoro, C. , Bamba, F. , Steve-Evanes, K. , Aurélie, V. and Vincent, C. (2021) Design, Synthesis and Antibacterial Activity Evaluation of 4,5-Diphenyl-1H-Imidazoles Derivatives. Open Journal of Medicinal Chemistry, 11, 17-26. doi: 10.4236/ojmc.2021.112002.