Mouthwash with Active Oxygen (blue®m) Induces Keratinocytes Proliferation - Open Journal of Stomatology

OJST > Vol.10 No.6, June 2020

Open Journal of Stomatology

Volume 10, Issue 6 (June 2020)

ISSN Print: 2160-8709 ISSN Online: 2160-8717

Google-based Impact Factor: 0.49 Citations h5-index & Ranking

Mouthwash with Active Oxygen (blue^®m) Induces Keratinocytes Proliferation ()

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Download as PDF (Size: 629KB) PP. 107-114

DOI: 10.4236/ojst.2020.106012 589 Downloads 1,946 Views Citations

Author(s)

Bruna Marca Mattei¹, Soraia A. W. Imanishi¹, Grasieli de Oliveira Ramos¹, Paloma Santos de Campos², Suyany Gabriely Weiss³, Tatiana Miranda Deliberador³

Affiliation(s)

¹Department of Dentistry, Universidade do Oeste de Santa Catarina (UNOESC), Joaçaba, Brazil.
²Department of Dentistry, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.
³School of Health Sciences, Department of Dentistry, Universidade Positivo, Curitiba, Brazil.

ABSTRACT

Chlorhexidine is widely used in dentistry to treat various gingival conditions. Its side effects are widely described. Histologically, the gingiva consists of a stratified squamous epithelium, with a predominance of keratinocytes, the latter being fundamental in healing processes. Thus, the objective of this in vitro study was to evaluate the effects of a new product with active oxygen (blue^®m) on keratinocytes. Keratinocytes (HACAT) were incubated with different concentrations of blue^®m (1, 10 and 100 μl/ml), and another well was used as a control, without the presence of mouthwash. After 24, 48 and 72 hours, cell proliferation was analyzed by CyQUANT^{^®}. It was possible to observe that lower concentrations (1 μl/ml) of blue^®m increased cell proliferation in HACAT cell lines, while moderate and higher concentrations of mouthwash may present a cytotoxic effect. This is the first in vitro study with showing that human keratinocytes cell line demonstrated greater proliferation rate when exposed to lower concentrations of blue^®m mouthwash.

KEYWORDS

Keratinocytes, Cell Proliferation, Oxygen

Share and Cite:

Mattei, B. , Imanishi, S. , Ramos, G. , Campos, P. , Weiss, S. and Deliberador, T. (2020) Mouthwash with Active Oxygen (blue^®m) Induces Keratinocytes Proliferation. Open Journal of Stomatology, 10, 107-114. doi: 10.4236/ojst.2020.106012.

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[2]	A Narrative Review on Means to Promote Oxygenation and Angiogenesis in Oral Wound Healing. Bioengineering 2022, 9, 636
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[4]	Mouthwash with Active Oxygen (blue® m) Reduces Postoperative Inflammation and Pain
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[5]	Influência da aplicação do gel de liberação lenta de oxigênio em modelo animal de BRONJ: estudo de boca dividida
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