Carbon-carbon, Carbon-nitrogen and Carbon-sulfur Bond Formation Reactions

The construction of C-X (X = C, N, S) bonds is an important research content in the field of organic synthesis and drug preparation. Focusing on the green construction of the core skeleton of functional fine chemicals, the team has carried out research on green synthesis and catalytic reactions of fine chemicals, realized the effective synthesis of high value-added fine chemicals, and obtained a series of new systems of transition metal palladium and copper-catalyzed halogenated aromatic hydrocarbons involved in C-C and C-N coupling reactions; realized the efficient preparation of biphenyl, arylamine and aryl thioether compounds using water as solvent. Aiming at atomic economy, we realized the new method of direct C-H functionalization of arenes to construct C-C and C-S bond formation, as well as the construction of structurally complex functional molecular skeletons through one-pot multi-step reactions, laying a solid foundation for the application of fine organic synthesis technology in the fields of pharmaceutical intermediates, agrochemicals and optoelectronic materials, forming a distinctive research direction of fine chemical synthesis technology and it has formed a distinctive research direction of fine chemical synthesis technology and a stable R&D team, and improved the technical level of preparation of high value-added fine chemicals. He has published a total of 30 academic papers, including 27 SCI papers.

Sample Chapter(s)
preface (18 KB)

Components of the Book:

Preface

Chapter 1
Studies on the Formation Reactions of Carbon-Carbon Bonds

1. Bis(imino)pyridine palladium(II) complexes: synthesis, structure and catalytic activity
2. Preparation and catalytic properties of bis(imino)pyridine palladium(II) complexes as efficient catalysts for Suzuki cross-coupling reaction in water
3. Salen and half-salen palladium(II) complexes: synthesis, characteriztion and catalytic activity toward Suzuki-Miyaura reaction
4. Bis(imino)pyridine palladium(II) complexes as efficient catalysts for the Suzuki-Miyaura reaction in water
5. A rapid and efficient catalysis system for the synthesis of 4-vinylbiphenyl derivatives
6. Palladium-catalyzed direct arylation of polyfluoroarene and facile synthesis of liquid crystal compounds
7. Metallomicelles of palladium(II) complexes as efficient catalysts for the Suzuki-Miyaura reaction in neat water
8. One pot synthesis of polyfluoroterphenyls via palladium-catalyzed Suzuki-Miyaura coupling of chlorobromobenzene and C-H bonds functionalizations of perfluoroarenes
9. Synthesis of terphenyl derivatives by Pd-catalyzed Suzuki-Miyaura reaction of dibromobenzene using 2N2O-Salen as a ligand in aqueous solution
10. Water-soluble salen-Pd complex as an efficient catalyst for Suzuki-Miyaura reaction of sterically hindered substrates in pure water
11. 3-(Diphenylphosphino)propanoic acid: an efficient ligand for the Pd/Cu-catalyzed homo-coupling of terminal alkynes in the presence of oxygen at room temperature
12. Synthesis of symmetrical terphenyl derivatives by PdCl2-catalyzed Suzuki-Miyaura reaction of dibromobenzene using 3-(diphenylphosphino)propanoic acid as a ligand
13. Synthesis of unsymmetrical 1,3-Diynes via Pd/Cu-catalyzed cross-coupling of terminal alkynes at room temperature
14. Multi-component one-pot reaction of aromatic carbonyl compounds, tosylhydrazide, and arylboronic acids
15. Pd-Catalyzed chemoselective Suzuki-Miyaura reactions of 1-bromo-4-(halomethyl) naphthalene
16. Pd-catalyzed, highly selective C(sp2)-Br bond coupling reactions of o- (or m-, or p-) chloromethyl bromobenzene with arylboronic acids

Chapter 2
Studies on the Formation Reactions of Carbon-Nitrogen Bonds

17. 3-(Diphenylphosphino)propanoic acid: An efficient ligand for the Cu-catalyzed N-arylation of imidazoles and 1H-pyrazole with aryl halides
18. A simple and efficient 2N2O-Cu(II) complex as a catalyst for N-arylation of imidazoles in water
19. Salen-Cu(II) complex catalyzed N-arylation of pyrazole under mild conditions
20. Pd-catalyzed N-arylations of 3-aryl-1-tosyl-1H-pyrazol-5-amines with arylbromides and the migration of Ts group

Chapter 3
Studies on the Formation Reactions of Carbon-Sulfur Bonds

21. Cu-catalyzed direct C-H thiolation of electron-rich arenes with arylsulfonyl hydrazides
22. NH4I/1,10-Phenanthroline catalyzed direct sulfenylation of N-heteroarenes with ethyl arylsulfinates
23. Cu-catalyzed direct bis-thiolation of benzoheterocyclics with arylsulfonyl hydrazides
24. TBAI-Mediated sulfenylation of arenes with arylsulfonyl hydrazides in DPDME
25. Sulfenylation of arenes with ethyl arylsulfinates in water
26. The fast and efficient KI/H2O2 mediated 2-sulfonylation of indoles and N-methylpyrrole in water
27. Facial synthesis of sulfinic esters via copper-catalyzed reaction of sulfonyl hydrazides with alcohols in air

Readership: Students, academics, teachers and other people attending or interested in Carbon-sulfur Bond Formation Reactions.

3		Preface Ping Liu PDF (18 KB)

9		Chapter 1 Studies on the Formation Reactions of Carbon-Carbon Bonds Ping Liu PDF (2447 KB)

147		Chapter 2 Studies on the Formation Reactions of Carbon-Nitrogen Bonds Ping Liu PDF (742 KB)

187		Chapter 3 Studies on the Formation Reactions of Carbon-Sulfur Bonds Ping Liu PDF (2213 KB)

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Ping Liu
Ping Liu was born in August 1979, PhD, Professor, and Master Supervisor. He received his bachelor’s degree in applied chemistry from Yanbian University in 2002, his master’s degree in organic chemistry from Yanbian University in 2005, and his doctorate degree in applied chemistry from Dalian University of Technology in 2010. He is a member of Huang Danian Teacher Team of National Universities-Xinjiang Advantageous Resources Chemical Utilization Teacher Team. He is mainly engaged in the resea

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