Chemistry is a subject that makes human life better. In the past few hundred years, the development of modern chemistry has also explained this meaning perfectly. Naturally, supramolecular chemistry also needs to move from theory to application, from laboratory to society, and ultimately benefit mankind.
Insoluble drugs refer to poorly water-soluble drugs, which will lead to difficult absorption and transportation in vivo and low bioavailability. About 40% of the newly discovered natural active substances and nearly 60% of the chemically synthesized drugs are insoluble drugs. Their solubility (in water) is poor and it is difficult to achieve satisfactory clinical efficacy, so they have not been successfully developed into new drugs. Natural β-cyclodextrin can form supramolecular inclusion complexes with insoluble drugs, thus increasing the solubility of insoluble drugs. As a new drug delivery carrier, it has been widely studied and applied. Sulfobutyl eth-er-β-cyclodextrin is a derivative of β-cyclodextrin. Because of its good water solubility and biocompatibility, sulfobutyl ether-β-cyclodextrin can sig-nificantly increase the solubility, bioavailability and low nephrotoxicity of drugs. As a new type of injection drug delivery carrier, it has become one of the hot spots in the research and development of new drugs at home and abroad.
Sample Chapter(s)
Preface (129 KB)
Components of the Book:
- Head Page
- Copyright
- About the author
- Preface
- content
- Chapter 1 Review of Cyclodextrin Inclusion Complex
- 1.1 Introduction of Cyclodextrin
- 1.2 Structure and Physiochemical Properties
- 1.3 Effect of Chemical Modification on the Properties of Cyclodextrin
- 1.4 Application Fields of Cyclodextrin Inclusion Materials
- 1.5 Application of β-CD and Its Derivatives in Pharmacy
- Chapter 2 Preparation and Properties of Cyclodextrin
Inclusion Complex
- 2.1 Structure and Formation Mechanism of Cyclodextrin Inclusion Complex
- 2.2 Thermodynamics of Inclusion 52
- 2.3 Interaction between Drug and Cyclodextrin
- 2.4 Preparation of Inclusion Compound
- 2.5 Factors Affecting Inclusion Effect
- 2.6 Screening of Preparation Conditions of Inclusion Complex
- Chapter 3 Analysis and Identification of Cyclodextrin
Inclusion Complex
- 3.1 Change of Guest Molecular Properties
- 3.2 Analysis of Cyclodextrin Inclusion Complex
- 3.3 Identification of Cyclodextrin Inclusion Complex
- 3.4 Reference
- Chapter 4 Preparation and Evaluation of ZIP-SBE-β-CD
Inclusion Complex
- 4.1 Introduction
- 4.2 Experimental Methods
- 4.3 Results and Discussion
- Chapter 5 Conclusion
Readership:
Students, academics, teachers and other people attending or interested in Cyclodextrin Inclusion Complex.
Yanfei Miao
Miao Yanfei, born in Donghai, Jiangsu Province, China, doctor of Pharma-ceutical Engineering, currently teaching in Taishan University, mainly en-gaged in the research of new technology of pharmaceutical preparations.