Before the system theory came into being, our understanding of biology is still based on the basis of decomposition and reduction. If we're stuck in reductionism, many complex autoimmune diseases, such as Rheumatoid arthritis (RA), will be difficult to understand. With the emergence of complex networks in 1989, understanding of biological networks has been enhanced. In this book the author presents the management strategy of RA from the perspective of complex network.

RA is the most common chronic autoimmune joint disease. This book argues that the RA is mainly caused by chronic stress and stress factors include physical and psychological stress. Existing statistical techniques based on reductionism cannot discover many relevant disease risk factors and complex interaction relationship. The disease network model based on complex network is important for the analysis and treatment of RA disease.

In this book, the author have found five important layers of RA complex network and presented five balances regulating strategy in the management of RA. Using this method, the author takes a two-year follow-up to check the effect.

This Book argues RA is selflimiting to some extent, and good management with five balances regulating strategy would have positive significance, among which the balance between neuroendocrine system and immune system is the most important. All five balances regulating strategy are important for RA with other causes besides the RA case in the book.