Metabolic brain disease mainly results from inborn metabolic errors, primarily from enzymatic defects which lead to substrate accumulation, product reduction, or increase in toxic metabolites through alternate pathways. The majority of these conditions are familial, however spontaneous mutation may also occur in utero. Acquired or inborn metabolic brain diseases that produce brain dysfunction or damage. These include primary (i.e., disorders intrinsic to the brain) and secondary (i.e., extracranial) metabolic conditions that adversely affect cerebral function. Brain dysfunction or damage caused by acquired (i.e., non-inborn) metabolic disorders. Associated conditions include endocrine diseases; water-electrolyte imbalance; kidney diseases; liver diseases; anoxia (hypoxia, brain); nutritional disorders; an encephalopathy associated with hemodialysis; and other disorders.

In the present book, twelve typical literatures about metabolic brain disease published on international authoritative journals were selected to introduce the worldwide newest progress, which contains reviews or original researches on medical science, endocrine diseases, epidemiology, obese related disease, ect. We hope this book can demonstrate advances in metabolic brain disease as well as give references to the researchers, students and other related people.