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has been cited by the following article:

• TITLE: Polydopamine Particles Effect on Melanoma Cells Proliferation and Melanin Secretion

  AUTHORS: Sandy Eap, Alice Ferrand, Valérie Machi, Vincent Ball, Olivier Huck, Nadia Benkirane-Jessel

  KEYWORDS: Polydopamine Particles; Polyelectrolyte Multilayers Films; Melanin; Melanoma Cells

  JOURNAL NAME: Advances in Chemical Engineering and Science, Vol.3 No.3A1, July 12, 2013

  ABSTRACT: Melanin is a biopolymer implicated in the protection of cellular membranes and DNA produced by melanocytes. This pigment has a dual role and should be considered as a photo-protector and as a photosensitizer due to its interaction with UV. The design of multifunctional and biologically responsive coatings is of major interest in modern biomaterials science. The aim of this study is not only to characterize the deposition of multilayered polyelectrolytes films made from polydopamine particles and polyamines like poly-(L-lysine hydrobromide) (PLL), but also to evaluate melanoma cells activity in terms of proliferation and their capacity to stimulate melanin secretion. One could expect that the presence of a melanin like material in the film may have a positive or a negative feedback on the melanin biosynthesis and consequently on melanoma development. Some comparisons are also done with pure polydopamine grains in suspension in the cell culture medium, to investigate if the immobilization of the polydopamine grains has an influence on their bioactivity.