V. A. Fadok, D. L. Bratton, A. Konowal P. W. Freed, J. Y. Westcott and P. M. Henson, “Macrophages that Have Ingested Apoptotic Cells in Vitro Inhibit Proinflammatory Cytokine Production through Autocrine/Paracrine Mechanisms Involving TGF-β, PGE2, and PAF,” Journal of Clinical Investigation, Vol. 101, No. 4, 1998, pp. 890898. doi:10.1172/JCI1112

has been cited by the following article:

• TITLE: Down Regulation of MyD88 in Macrophages Treated with Liposomes Composed of Phosphatidylserine

  AUTHORS: Yuka Takasugi, Futoshi Kurai, Issei Kazume, Masaki Otsuka, Yoichi Negishi, Rui Tada, Yukihiko Aramaki

  KEYWORDS: Phosphatidylserine; Liposome; MyD88; TGF-β; Macrophage

  JOURNAL NAME: Pharmacology & Pharmacy, Vol.4 No.2, April 28, 2013

  ABSTRACT: We have recently demonstrated that liposomes composed of phosphatidylserine (PS-liposomes) suppressed nitric oxide and inflammatory cytokine productions following LPS stimulation in macrophages. In this study, we examined the effect of PS-liposomes on expressions of TLR-4 and MyD88, which are essential for the signal transduction in LPS stimulation. Expression of MyD88 was suppressed when macrophages were treated with PS-liposomes, but not with liposomes of phosphatidylcholine. No change in TLR-4 expression was observed. MyD88 suppression was restored to the control levels when cells were pre-treated with anti-TGF-β antibody, suggesting that TGF-β plays an important role in down-regulation of MyD88 following PS-liposome treatment.