Gosálvez, M. (1998) Producción de oxígeno por mito condrias filamentadas. Importancia para el cáncer y la neurodegeneración. Anales de la Real Academia Naci onal de Medicina, Tomo CXV, Cuaderno Tercero, 747 756.

has been cited by the following article:

• TITLE: Metabolic control of respiration and glycolysis of tumoral cells

  AUTHORS: Mario Gosalvez

  KEYWORDS: Energy Metabolism; Cancer; Mitochondrial Filamentation; Glycolysis; Respiration; Metabolic Control

  JOURNAL NAME: Advances in Biological Chemistry, Vol.3 No.1, February 26, 2013

  ABSTRACT: The contribution of the author’s groups on the control of energy metabolism of cancer cells has been concisely reviewed. It is proposed that Otto Warburg’s “respiratory defect” of tumoral cells resides in an alteration of the recurrent filamentation cycle of mitochondria. These give those organelles an affinity lower for ADP than the affinity of the tumor cell isoenzyme of pyruvate kinase. These two findings may explain the essentials of the intimate mechanism of the aerobic glycolysis of cancer cells.