Metabolic control of respiration and glycolysis of tumoral cells

Mario Gosalvez

Laboratorio y Servicio de Bioquímica Experimental, Clinica and Hospital Universitario Puerta de Hierro (1970-2010), Madrid and Majadahonda, Comunidad de Madrid, Spain.

DOI: 10.4236/abc.2013.31011                

Abstract

The contribution of the author’s groups on the control of energy metabolism of cancer cells has been concisely reviewed. It is proposed that Otto Warburg’s “respiratory defect” of tumoral cells resides in an alteration of the recurrent filamentation cycle of mitochondria. These give those organelles an affinity lower for ADP than the affinity of the tumor cell isoenzyme of pyruvate kinase. These two findings may explain the essentials of the intimate mechanism of the aerobic glycolysis of cancer cells.

Keywords

Energy Metabolism; Cancer; Mitochondrial Filamentation; Glycolysis; Respiration; Metabolic Control

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1]	Warburg, O. (1956) On the origin of cancer cells. Science, 123, 309-314. doi:10.1126/science.123.3191.309
[2]	Weinhouse, S. (1956) Oxidative metabolism of neoplastic tissues. Advances in Cancer Research, 3, 269-315. doi:10.1016/S0065-230X(08)60922-7
[3]	Chance, B. and Hess, B. (1959) Spectroscopic evidence of metabolic control. Science, 129, 700-708. doi:10.1126/science.129.3350.700
[4]	Pedersen, P.L, Grienwalt, J.W., Chan, T.L. and Morris, HP. (1970) A comparison of some ultrastructural and biochemical properties of mitochondria from Morris He patomas. Cancer Research, 30, 2620-2626.
[5]	Aisemberg, A.C. (1961) The glycolysis and respiration of tumors. Academic Press, New York.
[6]	Lo, C.H., Cristofalo, V.J., Morris, H.P. and Weinhouse, S. (1968) Studies on respiration and glycolysis in trans planted tumors of the rat. Cancer Research, 28, 1-10.
[7]	Weinhouse, S. (1972) Glycolysis, respiration and anoma lous gene expression in experimental hepatomas. Cancer Research, 32, 2007-2010.
[8]	Gosalvez, M., Lopez-Alarcon, L., Garcia-Suarez, S., Montalvo, A and Weinhouse, S. (1975) Stimulation of tumor-cell respiration by inhibitors of pyruvate kinase. European Journal of Biochemistry, 46, 133-140. doi:10.1111/j.1432-1033.1974.tb03605.x
[9]	Gosalvez, M., Garcia Suarez S. and Lopez Alarcón, L. (1978) Metabolic control of glycolysis in normal and tumor “permeabilized” cells. Cancer Research, 38, 142-148.
[10]	Gosalvez, M. and Perez-Garcia, J. (1971) Action of chemical carcinogens on electrón transport and energy in isolated mitochondria. Proceedings 7th FEBS Meeting, Varna, No. 621, 232.
[11]	Gosálvez, M., Díaz-Gil, J., Coloma, J. and Salganicoff, L. (1977) Spectral and metabolic characteristics of mitochondrial fractions from rotenone-induced tumours. British Journal of Cancer, 36, 243-253. doi:10.1038/bjc.1977.184
[12]	Gosalvez, M., Blanco, M.., Testillano, P.S. and Risue?o, M.C. (1996) Warm low stress isolated filamentous mitochondria. Cellular and Molecular Biology, 42, Abstract 4.
[13]	Gosalvez, M. and Blanco, M. (1998) Oxygen production by filamentous mitochondria. Proceedings of Abstract ISOTT’98, Budapest, Abstract 08.
[14]	Gosálvez, M. (1998) Producción de oxígeno por mito condrias filamentadas. Importancia para el cáncer y la neurodegeneración. Anales de la Real Academia Naci onal de Medicina, Tomo CXV, Cuaderno Tercero, 747 756.
[15]	Gosalvez, M. (2010) Mitochondrial filamentation. Proceedings 110th Meeting, AACR, Washington, 76, 20.
[16]	Gosalvez, M. (2012) Reversal of cancer by dual strategy: A new molecular target? Proceedings 103rd AACR Meeting, Chicago, 31 March-4 April 2012, Abstract 4611, 1118.
[17]	Gosalvez, M. (2012) Mitochondrial filamentation: Some Methods of isolation and assay. IORS Journal of Pharmacy and Biological Sciences, 4, 37-39.