TITLE:
Antioxidant Supplement Improves the Pregnancy Rate in Patients Undergoing in Vitro Fertilization for Unexplained Infertility
AUTHORS:
Ayse Z. Ozdemir, Bulent Ayas, Davut Guven, Abdulkadir Bakay, Pervin Karlı
KEYWORDS:
CoQ10, Omega-3, Antioxidant, Unexplained Infertility, In Vitro Fertilization
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.9 No.1,
January
4,
2019
ABSTRACT: Objective: This is a retrospective study to evaluate the
effect of using the antioxidants containing coenzyme Q10 (CoQ10) and omega-3 in
patients undergoing in vitro fertilization and intracytoplasmic sperm injection (IVF-ICSI) for unexplained
infertility. Materials Methods: A total of 299 patients
undergoing IVF-ICSI for unexplained infertility at the IVF center of Ondokuz
Mayis University were studied. The subject group consisted of 135 patients who
used OMEPA Q10 (Co Q10 100 mg, omega-3 600 mg, eicosapentaenoic acid 300 mg,
docosahexaenoic acid 230 mg) for two months before ovarian stimulation. A group
of 164 patients who did not use the supplement were evaluated as the control
group. Results: The pregnancy rate of patients using antioxidants
was statistically higher than that of those who did not use the supplement (p 0.05). The pregnancy rates of patients in the two
groups were 32.9% and 49.6% respectively. The pregnancy
rate of patients using antioxidants was statistically higher than that of those
who did not use the supplement (p 0.05) seemed not enough. Conclusion: We concluded that using antioxidants that contain Co
Q10 and omega-3 in patients undergoing IVF-ICSI for unexplained infertility
increased the clinical pregnancy rate. We recommend using antioxidants that contain Co Q10 and omega-3
in infertile patients.