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has been cited by the following article:

• TITLE: Optimization of the Extraction Technology of Chlorogenic Acid in Honeysuckle by Response Surface Method

  AUTHORS: Tingting Cui, Chao Wang, Changsong Shan, Peng Wu

  KEYWORDS: Design-Expert Software, Lonicera Japonica, Chlorogenic Acid, Extraction Technology Optimization

  JOURNAL NAME: Open Access Library Journal, Vol.1 No.6, September 12, 2014

  ABSTRACT: The ultrasound-assisted extraction of chlorogenic acid from honeysuckle was modeled using response surface methodology. A three-level-three-factor Box–Behnken design was employed to optimize three extraction variables, including extraction temperature (X1), ethanol concentration (X2), and soak time (X3), for the achievement of high extraction yield of the chlorogenic acid. The optimized conditions are extract temperature of 80℃, ethanol concentration of 70.37%, soak time of 9.35 h. Under this optimized conditions, the experimental yield of chlorogenic acid is 1.918%, which is well matched with the predicted yield of 1.929%.