Highly Efficient Synthesis of Novel Fluorine Bearing Quinoline-4-carboxylic Acid and the Related Compounds as Amylolytic Agents

Mohammed S. T. Makki, Dina A. Bakhotmah, Reda M. Abdel-Rahman

Department of Chemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.

DOI: 10.4236/ijoc.2012.21009                

Abstract

Highly efficient syntheses of novel fluorine bearing quinoline-4-carboxylic acids and the related compounds had been achieved from cyclocondensation of 2-amino-5-fluorophenyl glyoxylic acid 1 with benzoyle asetanilides 2 in boiling DMF, to give the target 3. Decarboxylation of 3 produced 6-fluoro-2-phenyl-3-(substituted amino)-keto-quinolines 4, while that reaction underwent refluxing, afforded 7-fluoro-1-(aryl)-3-phenyl-pyrrolo[3,4-c] quinoline-2,9-diones 5. Structure of the products has been established from their elemental and spectral analysis. All targets exhibited a high to moderate activity against some Aspergillus fungi as amylolytic agents.

Keywords

Amylolytic Activity; Amylolytic Agents; Aspergillus fungi; Efficient Synthesis; Fluoroquinoline;Quinoline-4-carboxylic Acids

Conflicts of Interest

The authors declare no conflicts of interest.

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